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Why Moderna’s COVID-19 vaccine results represent more good news for Canada

A second company touting the results of its potential COVID-19 vaccine Monday represents particularly good news for Canada.

Citing early results, Massachusetts-based Moderna said its vaccine candidate could be as much as 94.5 per cent effective. The announcement follows results reported by that hinted at as much as 90 per cent immunity for that company’s vaccine candidate.

Canada already has a contract in place for 56 million doses of the Moderna vaccine and 20 million doses of Pfizer’s candidate, should they complete testing and receive Health Canada approval.

The new Moderna results are an early look at the final stage of human testing, but the trial isn’t done yet, so things could change. While results have been examined by an independent data safety monitoring board, they have yet to be published or peer reviewed.

At this point, the company says its results show no major safety concerns. Some volunteers reported mild or moderate symptoms, such as fatigue or headache.

“This is a pivotal moment in the development of our COVID-19 vaccine candidate. Since early January, we have chased this virus with the intent to protect as many people around the world as possible,” Stéphane Bancel, chief executive officer of Moderna, said in a statement.

Both Pfizer and Moderna are using a new technology that relies on mRNA to make their vaccines. Their doses include a tiny recipe for spike protein DNA, and, in theory, will prompt the recipient’s immune system to fight off future coronavirus infections. Because of the similarity in approaches, many experts were anticipating the two vaccines would see similar efficacy rates.

While RNA is a technology that has been considered promising for awhile, it has had one major drawback: the fact that doses have had to be stored at a temperature as cold as -80 C, which means an eventual distributor would need access to refrigerators and trucks .

But Moderna said Monday that its candidate remains stable at 2 to 8 C, which is about the same as a normal refrigerator, for 30 days.

“We believe that our investments in mRNA delivery technology and manufacturing process development will allow us to store and ship our COVID-19 vaccine candidate at temperatures commonly found in readily available pharmaceutical freezers and refrigerators,” chief technical operations and quality officer Juan Andres said in a release.

Pfizer’s and Moderna’s are two of the seven candidate vaccines for which the federal government has locked down advance purchase agreements. Most of the candidates are being developed by companies in the U.S. and Europe, but one Canadian company, , is expanding its trials on Canadian volunteers this week.

Canada’s vaccine-procurement strategy can be best described as putting . If all seven candidates were to be approved, Canada would be entitled to a minimum of 358 million doses of vaccine.

Most of the vaccine candidates will require two doses per person, but that is still almost enough to vaccinate everyone in the country five times.

That said, getting a working vaccine is only the first step. Once a vaccine has its final testing results, Health Canada must decide whether to approve it.

Then, millions of doses have to be manufactured — a process that is already scaling up — and the government will have to figure out how to distribute it across the country. The federal government is currently trying to find a to take on that task. Actual vaccination programs will be run by the provinces and territories.

After Pfizer announced promising results last week, Prime Minister Justin Trudeau said he expects the first vaccine doses to land as early as the beginning of next year.

Correction — Nov. 16, 2020 — This article has been updated to reflect new statements from Moderna on the storage requirements of its vaccine. As well, Canada would be entitled to a minimum of 358 million doses, not 358 doses, of vaccine if all seven vaccine candidates were to be approved.

What you need to know about COVID-19 antibodies from someone who has them

May Warren is a Star reporter in the Health and Science unit to discuss her experience with a probable case of . At the time, she did not qualify for a test because she wasn’t in the priority list of people needing testing.

It was not until recently when Warren had a test to look for virus antibodies that she was able to confirm she had COVID in the spring. She returns to This Matters today to tell us about how that test went, what the results means, and what the importance of antibodies are in the fight against the pandemic.

Listen to this episode and more at or subscribe at , , or wherever you listen to your favourite podcasts.

York Region avoided a lockdown. But with ‘concerning’ COVID-19 numbers, can it escape the fate of Peel and Toronto?

Two weeks after York Region managed to avoid being locked down like its neighbouring municipalities, continue to climb with local hospitals above or nearing capacity and some areas seeing startling numbers of people testing positive. But the region has yet to sound the alarm.

York’s current infection rate of 111 cases per 100,000 population per week is higher than what Toronto was reporting on the day it entered lockdown, Nov. 23, according to the Star’s ongoing tally. The region logged 202 new COVID-19 infections on Dec. 2 and has a test positivity rate of 6.29 per cent, which is above the rate Toronto reported the week leading up to its lockdown.

As well, new data released Wednesday by the Toronto-based non-profit ICES (formerly the Institute for Clinical Evaluative Sciences) revealed an area within York Region that borders Brampton has a test positivity rate of 20.4 per cent — the second highest in the province.

York Region’s associate medical officer of health, Dr. Alanna Fitzgerald-Husek, said the thresholds are being monitored closely, but stayed away from saying the region was closer to a complete lockdown.

“The numbers are concerning and it is something we are monitoring,” she said. “The overall numbers and the curve going up is a concern, but what is really important to us is unpacking that curve and understanding where that burden is.”

On Nov. 20, the province announced were going into a lockdown, including a shutdown of non-essential retail, to help curb climbing rates of COVID-19. York, despite its consistently high numbers, managed to stay in the red-control zone, which allowed its businesses to stay open with reduced numbers, and limits on gatherings.

Fitzgerald-Husek said the situation in Peel and Toronto was “markedly different” in that they had consistently higher numbers and rates of cases a few weeks back compared to York. She said that while the region’s numbers have gone up, it is “still managing with contact tracing,” a key component of the public health response.

“We do have a good public health capacity; we are reaching our positive cases within 24 hours,” she said. “Our incidence rates are a bit higher, so that is something we are monitoring closely. We have been in the red-control zone for a couple of days and we are looking to see if the current trajectory is going down, as it takes about 10 to 12 days before (cases) decline.”

She said the data is being closely monitored, and a “sustained large change” could prompt a lockdown.

Ashleigh Tuite, an epidemiologist at the University of Toronto, said it’s already clear the red-control measures have not worked to “bend the curve” in York.

“There’s no reason to expect that cases are going to start declining on their own without some additional measures in place,” she said. “It’s the just the way communicable disease spread works; you have to change something if you want to change that trajectory.”

According to the ICES data that covers the last full week of November, six areas in York Region had test positivity rates higher than six per cent. Among them was an area that borders Brampton and includes Kleinburg that was the second highest in the province, with a 20 per cent positivity rate.

The second highest area in York Region was in Markham, just north of Steeles and east of Brimley, that had a positivity rate of 13.6 per cent, while the area with the third highest rate in the region included Concord, just north of York University, that had a positivity rate of 13.1 per cent, the data shows. The other areas with rates higher than six per cent were in Woodbridge, Maple and northeast Markham.

Fitzgerald-Husek said officials are closely watching all public health metrics, including hospital and health-care capacity in the region.

Markham Stouffville Hospital is operating above 100 per cent capacity and staff are using every available space to care for patients, said president and CEO Jo-anne Marr, noting the hospital is so far able to keep up with almost all its pre-COVID hospital services while catching up on a backlog of diagnostic procedures from the first wave.

In the past month, the hospital has seen a slow but steady increase in the number of admitted COVID-19 patients and is currently caring for 15 COVID-positive patients and 25 who are awaiting test results, she said. The test positivity rate at its assessment centre has fluctuated around 10 per cent in recent weeks, though a hospital spokesperson said it “is not a reflection of the rate in York Region because we are seeing many patients coming to the centre from areas across the GTA.”

Marr said she and the other hospital CEOs in York Region speak regularly with public health officials, and while the hospital is “under extreme pressures” it is so far managing.

“I do know that the capacity within York Region Public Health has been relatively strong … I think that has helped the region to avoid — at least to date — the lockdown.”

Mackenzie Richmond Hill Hospital is nearing capacity and is caring for 34 patients with suspected COVID-19 and 24 confirmed COVID-positive patients, 10 of whom are in intensive care.

Mary-Agnes Wilson, Mackenzie Health’s executive vice-president, chief operating officer and chief nursing executive, said the hospital has reached 90 per cent of its critical care capacity. In October, the hospital opened an additional eight ICU beds after receiving support from the province.

“That’s been our saving grace in terms of our critical care, because we’re well above the baseline 30 beds that we had prior to this investment.”

Wilson said the challenge for hospitals during the fall wave is they are managing COVID-19 activities, including caring for critically ill COVID patients, running assessment centres and providing support to long-term-care homes, all while maintaining regular hospital services.

“At this point in time, we’re doing 96 per cent of our pre-COVID in-patient activity and about 86 per cent of our outpatient activity; we’re hoping to maintain that access for patients.”

Wilson said the hospital has plans for a second dedicated COVID-19 unit, should the need arise.

Local politicians, meanwhile, are optimistic that stricter enforcement measures that have been put into place beyond provincial controls will help control COVID-19 case numbers, especially as people from nearby municipalities have recently been flocking to York Region malls for seasonal shopping.

Markham Mayor Frank Scarpitti, who has been vocal about safety measures since the start of the pandemic, said Regional Council decided to stay in the red zone on the recommendation of the region’s medical office of health, Dr. Karim Kurji, to the province.

At the time, after the region had recently moved into the red-control zone, Kurji told council that businesses were largely compliant with the additional safety measures that had been put forth, and that hospitals in the region were managing demand.

“We had seen the red zone work in the past, so the thinking was let’s give this a bit more time,” he said.

Scarpitti said he supported the decision on the basis that the region increased enforcement of those who weren’t compliant with social distancing rules, and that the province or region would implement a refined red zone allowing for capacity restrictions and physical distancing within retail and big-box stores, and limitations for religious gatherings in banquet halls.

Scarpitti said that when the province did not change the rules, Kurji issued an order under Section 22 to apply these restrictions.

Over the weekend, the York Region COVID-19 enforcement task force was out conducting 1,039 inspections, laying 42 charges and was involved in 737 education and compliance activities. Among those charged were Promenade Mall, Dollarama, Longo’s and Costco. The majority of the fines are for $880 and range from a failure to maintain physical distancing to lack of mask wearing.

Noor Javed is a Toronto-based reporter covering current affairs in the York region for the Star. Follow her on Twitter:

Megan Ogilvie is a Toronto-based health reporter for the Star. Follow her on Twitter: